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This outcome was prevented by co-administration of the CB1 receptor antagonist SR141716a, but not by co-administration in the CB2 receptor antagonist SR144528, suggesting this action of WIN55,212-two is mediated via
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the CB1 receptor. Administration of SR141716a alone experienced no have an impact on within the noticed allodynia and hyperalgesia, which doesn't guidance the concept of an endogenous analgesic tone.
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